Written by Dr. Neethu Susan Sunny

Medically reviewed by Dr. Israa Ismail

Updated on March 07, 2025

Bioidentical Hormone Treatment for Menopause: Benefits and Risks

Night sweats, Hot Flashes, Fatigue and Low Energy- Struggling with menopause symptoms?

A natural solution may be just what you need!

What if a natural hormone treatment could bring you relief? Bioidentical Hormone Replacement Therapy(BHRT) might be the answer you are looking for.

BHRT has now become a popular choice for many women for its perceived “natural” benefits and to ease those pesky symptoms of menopause. This natural therapy supplements hormones like estrogen, progesterone, and testosterone, which are chemically identical to those naturally produced by the body. 

Read more to know: What Happens to Your Hormones During Menopause: Taking a Closer Look

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Can you believe that hormones used for BHRT are derived from plants?

It sounds almost too good to be true, but bioidentical hormone replacement therapy has made it possible. Unlike synthetic hormones, BHRT uses plant-derived hormones that are chemically identical to those our bodies produce.

But before jumping in, it is important to weigh both the benefits and risks of this natural approach. In this guide, let’s explore BHRT in detail.

What Is Bioidentical Hormone Replacement Therapy (BHRT)?

Imagine using something your body recognises as its own- that is exactly what BHRT offers.

BHRT offers a targeted way to navigate menopause with confidence. This natural solution uses hormones structurally identical to those your body naturally produces. It is primarily designed to replenish declining levels of estrogen, progesterone and testosterone during menopause.

Most bioidentical hormones are derived from plant compounds found in soy and yams.

Through a special process, these plant-based compounds are converted into hormones that work in harmony with your body’s unique needs.

Renowned Media mogul Oprah Winfrey, often hailed as the voice of millions and advocate for women’s wellness, shared her transformation with BHRT, stating:

“After one day on bioidentical estrogen, I felt the veil lift. After three days, the sky was bluer, my brain was no longer fuzzy, and my memory was sharper. I was literally singing and had a skip in my step.”

-Oprah Winfrey

 

Her experience empowers women to take control of their menopause journey and to explore their options confidently.

Types of Bioidentical Hormones

a) FDA-Approved BHRT: 
Safe, regulated hormones such as estradiol and micronised progesterone ensure consistent results backed by science.

b) Compounded BHRT: 
Custom-made formulations are prepared by specialised pharmacies, often tailored to individual needs.

Common Symptoms Treated with BHRT

The rollercoaster of menopause is real, but it doesn’t have to be your everyday reality.

BHRT can help manage the most challenging symptoms of menopause:

  • Hot flashes and night sweats
  • Vaginal dryness and discomfort
  • Mood swings, anxiety, and depression
  • Sleep disturbances
  • Reduced libido
  • Fatigue and lack of focus

The bioidentical hormone therapy for menopause symptoms helps women feel empowered, energised and in control once again.

“My reason for joining Nirva was to manage my menopause symptoms.  Happily, most of (not all) my symptoms have now gone, or I can manage them very well. I also have my wonderful supportive Health Coach, Dr Mebil.”

-Rose Foster, a Nirva Health client review

 

If you want to manage your menopause symptoms with the right support and personalised guidance, Join us at Nirva Health.

Benefits of BHRT for Menopause

BHRT provides not only symptom relief but also long-term benefits. Find out how this therapy can help you feel better naturally.

A. Relief from Menopause Symptoms
Wave goodbye to those uncomfortable hot flashes, night sweats and vaginal dryness. BHRT improves mood, focus, and overall quality of life.

B. Bone Health Support
Estrogen in BHRT acts as a protector of your bones. It helps to maintain bone density and reduce the risk of osteoporosis.

C. Cardiovascular Health
Did you know BHRT can support your heart health, too? When started in the early stages of menopause, it may offer protective effects on heart health, potentially lowering the risk of heart disease (the concept called “timing hypothesis”).

D. IIndividualisedTreatment
Not all women are the same, and neither are their hormone needs. That’s why compounded BHRT can be tailored to match specific hormonal needs based on lab tests and symptoms.

E. Natural Appeal
Bioidentical hormones are derived from plant sources and may be perceived as safer than synthetic hormones. For many, this “natural” approach provides a sense of comfort and safety, making BHRT a go-to choice for women looking for a more holistic way to balance their hormones.

Risks and Concerns of BHRT

Are you wondering if a natural approach can cause you harm? While BHRT offers many life-changing benefits, it is also important to consider the risks and potential concerns.

Here is what you need to know before making a decision:

A. Lack of Standardisation Compounded BHRT
Compounded BHRT is not FDA-approved, meaning quality, consistency, and safety can vary significantly. If the dosage isn’t right, you may face over- or undertreatment.

B. Potential Side Effects
Yes! Some women may experience side effects. Though natural, it can lead to:

  • Nausea
  • Bloating
  • Breast tenderness
  • Headaches
  • Mood changes 

These symptoms typically go away after a short period, but for some, they might persist.

C. Increased Risk of Serious Conditions
It is essential to acknowledge the potential risks it may pose, especially for long-term use.

  • Breast Cancer: Prolonged use of estrogen and progesterone may increase the risk.
  • Blood Clots: Hormone therapy, especially oral forms, can raise the risk of thrombosis(blood clots)
  • Stroke: Women with other cardiovascular risk factors may face an elevated risk of stroke when using BHRT. 

D. Limited Long-Term Data
FDA-approved BHRT has been studied extensively, but there is limited research on the long-term safety of compounded BHRT.

It is crucial to monitor your body’s response to the therapy and consult your healthcare provider if needed.

Comparison: BHRT vs Traditional Hormone Therapy

So, let’s now see which hormone therapy is right for you.

When considering hormone therapy options, it’s important to understand the differences between Bioidentical Hormone Replacement Therapy(BHRT) and Traditional Hormone Therapy.

A study aimed at evaluating the evidence comparing bioidentical hormones with the commonly used non-bioidentical versions of HRT stated that:

“Physiological data and clinical outcomes demonstrate that bioidentical hormones are associated with lower risks, including the risk of breast cancer and cardiovascular disease, and are more efficacious than their synthetic and animal-derived counterparts.”

-PubMed.

 

Take a look at a quick comparison of both:

Aspect      BHRT        Traditional Hormone Therapy
SourcePlant-derived, bioidentical hormonesSynthetic or animal-derived hormones
RegulationFDA-approved or compounded(non-regulated)FDA-approved
CustomizationOften tailored to individual needsStandardized dosages
Safety DataLimited or compounded BHRTExtensive clinical studies available

 

The choice depends on your individual health needs, preferences, and risk tolerance.

Who Should Consider BHRT?

I’m not sure if BHRT is the right fit for you.

BHRT isn’t for everyone!

Here is who should and shouldn’t consider it:

Ideal Candidates:

  • Women struggling with severe menopause symptoms that impact their quality of life
  • Those looking for a more  “natural” hormone therapy option
  • Women who have tried and tolerated hormone therapy before without complications

Want to know more about the topic? Read on: Menopause And HRT: How To Know If It’s Time To Reevaluate

Who Should Avoid BHRT?

  • Women with a personal or family history of breast or uterine cancer
  • Individuals with a history of blood clots, stroke, or heart disease
  • Those with unexplained vaginal bleeding

Always make an informed decision before starting BHRT. It is essential to discuss your medical history and risks with your healthcare provider to ensure that it’s a suitable choice for you!

For any assistance, you can talk with the experts at Nirva Health.

How BHRT Is Administered

The right delivery matters!

Aren’t you curious to know how these bioidentical hormones are administered into your body?

There are various forms of BHRT that deliver the hormones. It offers options to suit your body’s needs. 

Let us break down the different available hormone delivery methods:

  • Oral Pills: Easy to take and convenient but may increase the risk of blood clots
  • Transdermal Patches or Gels: Deliver hormones through the skin, bypassing the liver

“Oral estrogens are converted to estrone by the liver before entering the bloodstream, while transdermal estrogens bypass the liver and retain their original form.”

-Dr Aswathy Krishna, Senior Ayurveda Consultant

 

  • Vaginal Creams or Rings: Ideal for targeted and localised relief of vaginal symptoms like dryness and discomfort
  • Injections or Pellets: Long-acting options for consistent hormone levels

Did you know?

Bioidentical hormones were first used for menopausal symptom relief in the 1930s. Canadian researcher James Collip first extracted an orally active estrogen from a pregnant woman’s urine, leading to the creation of Emmenin, an active agent.

Tips for Safe BHRT Use

If you are planning to use bioidentical hormones in your menopause journey, then take note of the following tips for a safe and effective approach.

  • Consult a Specialist: Work with a healthcare provider experienced in hormone therapy to evaluate your unique health needs, hormone levels and overall health.
  • Monitor your hormone levels and health markers frequently to ensure your progress and make adjustments as needed.
  • Begin with the lowest effective dose and gradually adjust as needed. This approach minimises the potential side effects while allowing your body to adjust to the hormone changes.
  • A healthy, balanced diet, regular exercise, and stress management enhance the benefits of BHRT and overall well-being

To know about how Ayurveda can influence your Hormonal balance- Read Ayurveda and Hormonal Imbalance: Nurturing Balance from Within

Wrapping up

Hey, ladies!

Is it time to take charge of your hormones to restore your health?

Could BHRT be the missing piece in your journey to hormonal balance?

By reading through it, you might have gotten the answer to these questions. Menopause can be made a pleasant affair by building bodily health and a positive mental outlook. A whole new life can be attained by a woman in menopause if she is wise enough to prepare for it and opt for proper hormone therapy.

The hormone therapy for personalised symptom relief of menopause- BHRT or Bioidentical Hormone Replacement Therapy helps reduce menopause symptoms while supporting heart and bone health, enhancing overall well-being

Though it is a natural hormone therapy for menopause, it is important to consider the risks, especially with compounded formulations. 

Remember to consult a healthcare expert to ensure that BHRT is the right choice for you.

Our expert team at Nirva Health is here to support and guide you at every step of your journey to wellness.

Book your appointment here.

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Dr. Neethu Susan Sunny

Dr Neethu Susan Sunny is an Ayurvedic physician and educator with expertise in Ayurvedic pharmaceutics and wellness management. She integrates her clinical knowledge and well-researched content to provide informed guidance on lifestyle corrections and holistic wellness through Ayurveda. With a focus on evidence-based practices, Dr. Neethu empowers individuals to embrace natural living as a sustainable path to long-term health and well-being.